Some examples; Sasuke thinking Naruto is dead(vs Haku), Itachi loosing his friend, Sasuke desperately trying to break a strong bond with his friend Naruto,Tobi loosing his crush, Madara loosing his brother.
In my opinion that kind of information can make Sasuke even stronger. Still Trying to figure out why the 1'st is so much like Naruto
i think Kishi really made a conserted effort to
make the First similar to Naruto and Madara to
Sasuke. Those two are like the modern day
Hashirama-Madara conflict and he is possibly
setting up another valley of the end battle. That is as long as Sasuke doesn't go good
on us after learning this new knowledge.