Re: VS Thread [With Manga Spoilers!]
I think that Sakura would be hard pressed against Shizune. Not that she isn't talented, but Shizune is a jounin (I'm making an assumption here because we saw her leading a team), which means she can manipulate at least 2 elements. As far as I know, Sakura doesn't have the ability to manipulate any.
I think that Sakura would also be at a disadvantage because Shizune is probably (given the immense amount of training from Tsunade) a better medical-nin than Sakura. As we have seen on multiple occasions, strength isn't everything.
I think that Shizune would be the winner here.