Re: Create your own plot twist
Shisui Uchiha is still alive; he was Madara's student along with Itachi before the massacre and he tried to steal Itachi's eyes to gain EMS. Itachi's crazed attitude during his fight with Sasuke was actually him imitating how Shisui acted when he tried to steal his eyes. Now he's hunting Itachi (who's also still alive) as a member of Akatsuki to kill him, take his eyes and gain EMS.
Oh, and Itachi wasn't responsible for the Uchiha Massacre, nor did Konoha order it. Madara killed off all the Uchiha because he believed they had prostituted themselves to Senju rule. Madara spared Sasuke only so that he could extort Itachi into working with him. Itachi then took blame for the massacre on Madara's orders so Sasuke would be spared.