Re: One Piece Franky
I don't know. I think its a possibility. They will be entering the New World where devil fruit users are more common and more rarer devil fruit abilities will pop up, like Marco's Mythical Zoan type for instance. I'd say in those two years of training the SH would have looked over all of their weakness and thought about how the road ahead of them will be like so I'd assume that they made as much preparations as can. Though they are newbies to the New World so they will run into some sticky situations.
Going back to your original question. I'd say its possible that Franky has some sort of defense against devil fruit users, especially the logia kind, and considering he overlooked Dr. Vegapunks data I'd say its even more likely. But who knows, maybe they will deal with that as they come across it, just like how Luffy came up with Gears 2 and 3 on the spur of the moment and how Chopper resorted to eating three Rumble balls. There was that Skypie arc where they came across the dials which they used to enhance the ship, tools, and weapons (Nami's Clima Tact).
The thing I love about Oda is how almost every little thing serves a purpose and its not aimlessly thrown about.
"Inherited will, the destiny of the age, and the dreams of its people. These are things that will not be stopped. As long as people continue to pursue the meaning of freedom, these things will never cease to be!"
-Gol D. Roger