Originally Posted by Vishnu
I don't think he would want to destroy something that could give him power. Though, he never showed any major interes in the Bijuu.
Orochimaru's plans began with the Bijuu. He intended to become powerful enough to become immortal. He needed a way to control them, and he began with the use of Hashirama's DNA. Those experiments created Yamato. When they failed him, he turned to the Uchiha and the Sharingan. He became obsessed with the Sharingan, becoming enamored with its ninjutsu-copying capability even moreso than its ability to control the bijuu.