Most Jounin teachers have been left in dust, sans Gai and Kakashi. Yamato is not a Senju (unless we haven't been told so hitherto) and I cannot see him using Hashirama's powers to even substantially hinder Madara, let alone match him. Madara was OP already without Hashi's DNA and the only reason we can conclude that he can fight so well with it is the lineage of the SOSP. Naruto has to beat Madara himself, as impossible as it may sound. There is no one else who has the sheer power to even trouble Madara in the least. This is the man who laid waste to all 5 Kages singlehandedly. Kinda makes me wonder how OP Hashirama was himself.

The whole series is like a redundant irony. With the powers the Uchiha had at their disposal, their annihilation seems meek at best and poorly forethought at worst. This includes techniques like Izanagi and Izanami which, unlike with the Mangekyou Sharingan's mention with only a handful of Uchiha, were not as rare and were said to have been used during wars... thereby leading one to question the simplicity and ease with which they whittled away.

Then again, not much in this manga seems to make sense anymore, so we never know.