I'm partial to Uchiha's, from they're inception, they never got a decent shot IMHO. Thats not saying they were the only ones, Kimmamaro's crew, and even Kushina's and others got wiped out, but between Madara, Harashirma, Tobirama, and the make up of the Uchiha brain, they were fucked at birth, all of them. To Tobirama, anything that wasn't Senju, or bowing to them was a problem seemingly.
Hit me tha right way, I gots no problem reppin' ya, and look for nothing in return. Just letting Ya know
You have dishonored my Family, and a Shaolin Temple...
許 Yurusenai 許