I'm partial to Uchiha's, from they're inception, they never got a decent shot IMHO. Thats not saying they were the only ones, Kimmamaro's crew, and even Kushina's and others got wiped out, but between Madara, Harashirma, Tobirama, and the make up of the Uchiha brain, they were fucked at birth, all of them. To Tobirama, anything that wasn't Senju, or bowing to them was a problem seemingly.
Just a Badass Crew...
"Why, Mr. Kyf? Why do you do it? Why get up? Why keep fighting? Do you believe you're fighting FOR something? For more than your Characters survival? Can you tell me what IT is? Do you even know? Is IT freedom? Or truth? Perhaps peace? Yes? No? Could it be for love? Illusions, Mr. Kyf. Vagaries of perception. The temporary constructs of a feeble human intellect trying desperately to justify a shinobi that is without meaning or purpose. And all of them as artificial as the Matrix itself, although only a human mind could invent something as insipid as love. You must be able to see it, Mr. Kyf. You must know it by now. You can't win. It's pointless to keep fighting. Why, Mr. Kyf? Why? Why do you persist?"
I speak 4 languages...
English, Profanity, Sarcasm, and Real Shit.