Originally Posted by Human Rasengan
Hashirama can negate any seals that minato places.. have you ever seen a tree grow alongside a chainlink fence. the wood eats the fence. whenever Minato trows a kunai hashirama can just make the wood swallow the kunai. and while Minato is "Jumping" Hashi is making the flowering jutsu to put Minato to sleep. assuming Minato can keep jumping and negate the field and goes to his far far away tag.. he eventually has to return to the battlefield.. Minato assuming the pollen is gone gets ready to come back.. but its too late hashi has made a wood clone that can sense through the earth.. minato come back but all his seals are in one spot because hashi moved themall right in the mist of his pollen jutsu and 1000 wood clones all in sage mode.. lol minato looses
If we're talking about what could be done, I said it before, and I'll say it again. Hashi can make wood come straight out of his body. So all he would have to do is cover the skin of his body with a layer of wood that looks like his actual skin in order to cover the vital points on his body, and his chakra could strengthen that wood to the point that no kunai could pierce through it deep enough to kill him. Minato would have to stab him through his eyes and into his brain just to kill him, which would require Minato to attack Hashi within Hashi's line of vision, which gives Hashi a chance to defend himself and counterattack.
And I seriously doubt if Hashi couldn't increase his speed to at level that surpasses Minato's speed just by using his buuji-level chakra in order to do so. Chakra has been shown to increase speed in this manga, I do believe.